Urbanization changes our lifestyles. With the size of the aging population growing, there will be more diabetics in China. As the patients get greater consumption power, the medical insurance system improves, and more innovative drugs for diabetes are developed, the diabetes drug market in China will be worth RMB 259.2 billion yuan by 2030.
The Chinese drug market for diabetes is dominated by traditional drugs. In 2018, the sales of GLP-1 drugs under this project were only RMB 700 million yuan, accounting for only 1.2%. The number during the same period in the United States was USD 5.6 billion, accounting for 15.5%. This suggests that there is huge growth room for GLP-1 drugs.
E2HSA is a long-acting drug with a long administration period. It needs to be administered once a week, with small dosage but high efficiency. The core yeast fermentation preparation process is cost-effective
Gene transfer >> Yeast expression >> Macromolecular protein production
The pipeline products include E2HSA and other approved type 2 diabetes treatment combination drugs, weight management drugs, interleukin-2 fusion protein tumor treatment adjuvant drugs.
Product | Use | Preclinical research, clinical phase I, clinical phase II, clinical phase III | Estimated completion date for the current phase |
E2HSA | Type 2 diabetes injection, GLP-1 weekly preparation, minimal hypoglycemia | December 2021 | |
E2HSA+Metformin | To treat type 2 diabetes, in combination with metformin | December 2024 | |
Interleukin-2 fusion protein | Adjuvant drugs for cancer treatment | Second half of 2022 |
Angdajiuli acquired 110 acres of land at No. 8 Shidai Road, Haining Economic Development Zone in October 2019, which will be used for the construction of GMP production plants. According to the company's listing plan, the project will be used as a fundraising project for the company's listing. (Left: plot diagram; middle: plant design; right: office building renderings).
Clinical Phase I was successfully completed in October 2019;
Clinical IIa will be successfully completed in December 2021;
Clinical Ⅱb and clinical Ⅲ will conduct joint trials. It is expected to complete the ethics declaration before the end of 2022, and to complete clinical Ⅲ in 2024 and obtain the new drug marketing license.
Sales Prediction The product is expected to be launched in the first half of 2025. Simultaneous plans to enter medical insurance in 2025, and sales are expected to start to achieve breakthrough growth in 2026, reaching 3.5 billion yuan in 2029. |
The estimated annual output of E2HSA will be RMB 3.5 billion, with a gross profit rate of 80%.
According to Ernst & Young and Frost & Sullivan, the market value of the project is RMB 2.5 billion (March 2020)
We offer 15% of the equity in this round of financing.
The company meets the listing requirements stipulated by Article 18A of the Hong Kong Stock Exchange, and has signed cooperation contracts with Shenwan Hongyuan Securities, Ernst & Young, Fangda Partners, Reed Smith, All Bright Law Office, Commerce & Finance Law Offices, and Frost & Sullivan. The listing is expected to be completed by the end of 2021.
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